Subscriber nudge+ 15,321 Posted August 1, 2019 Author Subscriber Share Posted August 1, 2019 I always feel bad for the animals involved in medical research (not only this one but in general), but other than that I'm definitely fine with this development. Could be a huge breakthrough in curing Type 1 diabetes and other chronic diseases and growing and harvesting organs for transplants; just another step to eradicating hereditary diseases in the future. There's always a possibility of things going wrong and technology being misused but everything comes with a cost anyway so... Link to comment Share on other sites More sharing options...
Subscriber CaaC (John)+ 5,358 Posted August 1, 2019 Subscriber Share Posted August 1, 2019 1 minute ago, nudge said: I always feel bad for the animals involved in medical research (not only this one but in general), but other than that I'm definitely fine with this development. Could be a huge breakthrough in curing Type 1 diabetes and other chronic diseases and growing and harvesting organs for transplants; just another step to eradicating hereditary diseases in the future. There's always a possibility of things going wrong and technology being misused but everything comes with a cost anyway so... I can understand that but I am not a vegetarian and I think sometimes that we are raising some animals to be butchered so we can eat them, you could class this as the same, it just makes me shiver that all the experiments on the animals involved you don't know or won't be able to tell if they are suffering from the experiments, they can't speak our language and tell us so. Link to comment Share on other sites More sharing options...
Subscriber nudge+ 15,321 Posted August 1, 2019 Author Subscriber Share Posted August 1, 2019 13 minutes ago, CaaC (John) said: I can understand that but I am not a vegetarian and I think sometimes that we are raising some animals to be butchered so we can eat them, you could class this as the same, it just makes me shiver that all the experiments on the animals involved you don't know or won't be able to tell if they are suffering from the experiments, they can't speak our language and tell us so. Yes, that's why I said that I also always feel sorry for them but I think it's justified as "necessary evil" of sorts - well as long as you look at it from the utilitarian point of view of mankind's progress, advancement and survival at least. Mind you, I'm only talking about medical/scientific research and testing here; all other sorts of testing for trivial commercial things like cosmetics should definitely be banned (and I'm glad it is in the EU). Truth is, every medical breakthrough in history involved animal testing and research at some point and this is no different... Link to comment Share on other sites More sharing options...
Subscriber Mel81x+ 3,607 Posted August 2, 2019 Subscriber Share Posted August 2, 2019 13 hours ago, nudge said: Japan approves first human-animal embryo experiments. https://www.nature.com/articles/d41586-019-02275-3 I love how every medical researcher always says something on the lines of "don't worry we will take all the necessary precautions". But overall, I am fine with it if it helps further disease prevention and may even unlock some other medical doors. Link to comment Share on other sites More sharing options...
Subscriber nudge+ 15,321 Posted November 1, 2019 Author Subscriber Share Posted November 1, 2019 There's a new docuseries about gene editing called Unnatural Selection on Netflix. Haven't seen it yet but might be worth a watch - although judging from the trailer it might be a rather one-sided view with a lot of fear-mongering and focused more on garage style biohacking than actual science. Link to comment Share on other sites More sharing options...
Subscriber nudge+ 15,321 Posted November 1, 2019 Author Subscriber Share Posted November 1, 2019 More "CRISPR babies" incoming (potentially). A good read showing how this new experiment would differ from the one that He Jiankui did in China despite of targeting the same gene. https://www.nature.com/articles/d41586-019-01770-x @Mel81x Link to comment Share on other sites More sharing options...
Subscriber Mel81x+ 3,607 Posted November 1, 2019 Subscriber Share Posted November 1, 2019 1 hour ago, nudge said: More "CRISPR babies" incoming (potentially). A good read showing how this new experiment would differ from the one that He Jiankui did in China despite of targeting the same gene. https://www.nature.com/articles/d41586-019-01770-x @Mel81x This right here "Rebrikov understands that if he proceeds with his experiment before Russia’s updated regulations are in place, he might be considered a second He Jiankui. But he says he would only do so if he’s sure of the safety of the procedure. “I think I’m crazy enough to do it,” he says." tells me all I need to know. He's going to do it and tell the regulatory bodies to go to hell. I think the way the laws are made now is absurd and if you dont run the tests how will you know the germline effect? Speculation? Doudna is the worst at these kinds of legalities and its no surprise the American government backs this while China has slowly had to yield due to pressure from the international community. I hope in the next 9 months Russian regulatory bodies say its okay so we can see what the chances are for a baby to survive birth with an HIV mother because right now the alternative is to condemn that child to HIV infection and then force that child to be medicated which runs into an agenda I think Big Pharma cares more about than gene therapy. Link to comment Share on other sites More sharing options...
AMG 227 Posted November 1, 2019 Share Posted November 1, 2019 Aldous Huxley Brave New World Link to comment Share on other sites More sharing options...
Bluewolf 7,161 Posted December 30, 2019 Share Posted December 30, 2019 Scientist who edited babies genes jailed for 3 years in China https://www.msn.com/en-gb/news/world/he-jiankui-scientist-who-edited-babies-genes-jailed-for-three-years/ar-BBYss7j?ocid=spartanntp Link to comment Share on other sites More sharing options...
Subscriber nudge+ 15,321 Posted December 30, 2019 Author Subscriber Share Posted December 30, 2019 4 hours ago, Bluewolf said: Scientist who edited babies genes jailed for 3 years in China https://www.msn.com/en-gb/news/world/he-jiankui-scientist-who-edited-babies-genes-jailed-for-three-years/ar-BBYss7j?ocid=spartanntp Moved this here as we discussed it quite a bit in the past in this thread. Can't shake the feeling that he's only been sentenced because the global public outrage made China look bad... Link to comment Share on other sites More sharing options...
Bluewolf 7,161 Posted December 30, 2019 Share Posted December 30, 2019 1 minute ago, nudge said: Can't shake the feeling that he's only been sentenced because the global public outrage made China look bad... Makes you wonder what might be going on behind closed doors in other countries... Link to comment Share on other sites More sharing options...
Subscriber nudge+ 15,321 Posted December 30, 2019 Author Subscriber Share Posted December 30, 2019 2 minutes ago, Bluewolf said: Makes you wonder what might be going on behind closed doors in other countries... Have you heard of Operation Paperclip? It was a secret US government/CIA operation that brought hundreds of ex-Nazi scientists into the US after the war and whitewashed their pasts in order to take advantage of their (often controversial) advancements in science and medicine including WMD, biological and chemical warfare and the likes... I have absolutely no doubt that every major country in the worlds is doing all they can to get their hands on medical/scientific/technological breakthroughs using all means necessary behind closed doors not caring about the"morality" and "ethics" whatsoever. Link to comment Share on other sites More sharing options...
Bluewolf 7,161 Posted December 30, 2019 Share Posted December 30, 2019 1 minute ago, nudge said: Have you heard of Operation Paperclip? It was a secret US government/CIA operation that brought hundreds of ex-Nazi scientists into the US after the war and whitewashed their pasts in order to take advantage of their (often controversial) advancements in science and medicine including WMD, biological and chemical warfare and the likes... I have absolutely no doubt that every major country in the worlds is doing all they can to get their hands on medical/scientific/technological breakthroughs using all means necessary behind closed doors not caring about the"morality" and "ethics" whatsoever. No I have never heard of it but totally agree with you on the other points, There is no way that they would halt trials/experiments on moral grounds because they all want to be the first to find new breakthroughs. It's just that what they do is kept so tightly under wraps that they have just not been caught out yet... It's frightening what they keep from the view of the masses in order to gain an edge...The same could be said of Technology breakthroughs.. Link to comment Share on other sites More sharing options...
Bluebird Hewitt 1,282 Posted December 30, 2019 Share Posted December 30, 2019 I've missed a fair bit of this. How close are we to seeing Solid Snake on the battlefield now? Link to comment Share on other sites More sharing options...
Subscriber Mel81x+ 3,607 Posted December 31, 2019 Subscriber Share Posted December 31, 2019 11 hours ago, Bluebird Hewitt said: I've missed a fair bit of this. How close are we to seeing Solid Snake on the battlefield now? Hehe he's already on the battlefield in many ways. Boston Dynamics is now doing work with the USG to start building terrain-agnostic machinery and there was some talk about an exo-skeleton which can be used to carry far more weight than humanly possible allowing for better carry. Back on topic, I don't know if China really needed to make this move. They've never given two shits about the international community when it comes to this and neither has Korea when it comes to weapon tech advancement (and they have some superb robotics integration). Most of their funding is government-backed and while this may look like something to appease the international community it may also be planned to allow better investor involvement in their ongoing plans in the biotech industry. Link to comment Share on other sites More sharing options...
Subscriber Mel81x+ 3,607 Posted February 27, 2020 Subscriber Share Posted February 27, 2020 https://arstechnica.com/science/2020/02/researchers-find-an-animal-without-mitochondria/ @nudge this is a nice short read and the comments section is quite entertaining too. Link to comment Share on other sites More sharing options...
Subscriber nudge+ 15,321 Posted February 27, 2020 Author Subscriber Share Posted February 27, 2020 9 hours ago, Mel81x said: https://arstechnica.com/science/2020/02/researchers-find-an-animal-without-mitochondria/ @nudge this is a nice short read and the comments section is quite entertaining too. A decent read. Multiple Star Wars references in the comments made me chuckle Link to comment Share on other sites More sharing options...
Subscriber nudge+ 15,321 Posted December 7, 2020 Author Subscriber Share Posted December 7, 2020 CRISPR-Cas9 gene editing successful for Sickle Cell Disease and transfusion dependent β-Thalassemia - more than a year later, the patients had clinically improved and no longer needed blood transfusions. https://www.nejm.org/doi/full/10.1056/NEJMoa2031054 https://www.sciencemag.org/news/2020/12/crispr-and-another-genetic-strategy-fix-cell-defects-two-common-blood-disorders A big breakthrough. Link to comment Share on other sites More sharing options...
Subscriber nudge+ 15,321 Posted April 11, 2021 Author Subscriber Share Posted April 11, 2021 A new breakthrough, sounds very promising - a new technique called CRISPRoff which is reversible and non-destructive (unlike traditional CRISPR), and the introduced epigenetic changes can be passed down to future lines of cells. https://interestingengineering.com/crispr-breakthrough-scientists-can-now-turn-genes-on-and-off-at-whim Link to comment Share on other sites More sharing options...
Subscriber nudge+ 15,321 Posted October 3, 2021 Author Subscriber Share Posted October 3, 2021 Now this is interesting... US startup Colossal Biosciences has announced plans to use CRISPR to bring woolly mammoths back from extinction and into the frosty landscape of the Siberian tundra. https://scitechdaily.com/startup-colossal-biosciences-wants-to-bring-woolly-mammoths-back-from-extinction-it-might-not-be-such-a-bad-idea/ Link to comment Share on other sites More sharing options...
Bluewolf 7,161 Posted October 3, 2021 Share Posted October 3, 2021 Interesting pros and cons for this type of thing.... Link to comment Share on other sites More sharing options...
Subscriber nudge+ 15,321 Posted October 3, 2021 Author Subscriber Share Posted October 3, 2021 8 minutes ago, Bluewolf said: Interesting pros and cons for this type of thing.... Imagine ordering mammoth ribs for a takeaway... Link to comment Share on other sites More sharing options...
Bluewolf 7,161 Posted October 3, 2021 Share Posted October 3, 2021 1 minute ago, nudge said: Imagine ordering mammoth ribs for a takeaway... Link to comment Share on other sites More sharing options...
Subscriber nudge+ 15,321 Posted October 3, 2021 Author Subscriber Share Posted October 3, 2021 In all seriousness though, this whole de-extinction topic is very fascinating. Imagine being able to bring back entire species, that's an incredible feat... Link to comment Share on other sites More sharing options...
Bluewolf 7,161 Posted October 3, 2021 Share Posted October 3, 2021 Just now, nudge said: In all seriousness though, this whole de-extinction topic is very fascinating. Imagine being able to bring back entire species, that's an incredible feat... Yea it is to be honest.. I also take their point about money going in to it that might be better used elsewhere but could we really afford to not see if it could be done??? Link to comment Share on other sites More sharing options...
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