Ibuprofen works most of the times, but once i had the worst toothache ever i took one and it didn't do nothing, after waiting like an hour hoping it would do something i decided to take another, and not only did it do nothing against the pain but i felt i was gonna die, my heart started pumping like crazy, i felt difficulty breathing and dizziness, it was actually strikingly similar than when i overdid it with coke! The funny thing is that a while after that i decided to go to ER and when i was sitting there waiting for them to take a look the pain magically went away, so in the end they didn't even take a look and i want back home. But long story short, i would advise against overdoing painkillers, if it says one each 6/8 hours respect it, because it will likely do more harm than good.