I think you're completely ignoring the context here, though. Her answer is to the host's (a man's) question about whether her work, while aiming to empower women, also targets men. To which she replies that yes, she likes to make men uncomfortable, because any significant, long lasting social change can only happen through difficult conversations and uncomfortable realizations. Her goal is not to make men uncomfortable in general because she wants them to be miserable lol, it's to make them see that maybe they themselves have those certain internalized attitudes that are the root of the problem. Which is pretty obvious when you think about the issues that she tackles in her work - women and child abuse, domestic violence, acid attacks and honour killings of women in Pakistan, rights of refugees and marginalized groups, Pakistani boys groomed in Taliban-run schools to carry out attacks against civilians, etc.